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Gaining weight in midlife may decrease dementia risk, study suggests

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A study of nearly 2 million people in Britain suggests an unexpected protective effect against dementia: obesity in midlife.

The research, published Friday in the journal The Lancet Diabetes & Endocrinology, linked a 34 percent increased risk of dementia among people who had a BMI of less than 20 kg/m2. A BMI of 18.5 is considered to be underweight. Meanwhile, the study findings linked very obese people— those with a BMI greater than 40— to having a 29 percent decreased risk of dementia.

Study authors, from the London School of Hygiene & Tropical Medicine, did not examine the reasoning behind the link, but in a news release, they noted their findings contradict previous research that suggests obesity increases dementia risk.

Researchers collaborated with global data research firm OXON Epidemiology to analyze the study participants’ medical records from the Clinical Practice Research Datalink, a database comprising about 9 percent of the United Kingdom population. Study participants had a median age of 55 and an average BMI of 26.5, which is considered overweight, at the beginning of the study. During an average nine years of follow-up, nearly 50,000 people were diagnosed with dementia.

The authors noted a gradual declining trend of dementia risk above a BMI of 25, which is considered healthy, up to 35 and higher. The participants’ birth year, age of diagnosis, as well as potentially confounding factors believed to increase dementia risk— like alcohol use and smoking— didn’t impact the results significantly, the news release said.

 Lead study author Nawab Qizilbash, of OXON Epidemiology, and an honorary senior lecturer at the London School of Hygiene & Tropical Medicine, said further research is needed to identify the reason behind the link.

“If increased weight in mid-life is protective against dementia, the reasons for this inverse association are unclear at present,” he said in the news release. “Many different issues related to diet, exercise, frailty, genetic factors and weight change could play a part.”

Study author Stuart Pocock, medical statistics professor at the London School of Hygiene & Tropical Medicine, said his team’s initial findings may hold promise for future dementia treatment.

“Our results suggest that doctors, public health scientists, and policy makers need to rethink how to best identify who is at high risk of dementia,” Pocock said. “We also need to pay attention to the causes and public health consequences of the link between underweight and increased dementia risk, which our research has established. However, our results also open up an intriguing new avenue in the search for protective factors for dementia.”

Researchers noted in the release that their threshold for “underweight” in the study was 20 kg/m2, which is slightly higher than the BMI usually considered to be underweight, 18.5 kg/m2, to allow for more direct comparison with earlier dementia and BMI studies.

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Europeans’ white skin developed later than thought

Europeans' white skin developed later than thought

Sweden’s Crown Princess Victoria and Prince Daniel in 2011. Traits of white skin emerged more recently than thought in Europe. (AP Photo/Lehtikuva/Vesa Moilanen)

Science notes that Europe is often thought of as the “ancestral home of white people.” But a new DNA study suggests that pale skin and other traits we associate with the continent may have emerged only within the last 8,000 years—a “relatively recent” occurrence.

The study—published last month on the bioRxiv.com server and presented last week at the American Association of Physical Anthropologists’ annual meeting—compared genome DNA across three populations of farmers and hunter-gatherers who crossed over into Europe in discrete migrations within the past eight millennia, Science notes.

What scientists found: a handful of genes tied to diet and skin pigmentation that withstood natural selection and thrived in the northern regions. The data indicates hunter-gatherers who settled in Spain, Hungary, and Luxembourg about 8,500 years ago lacked two specific genes—SLC24A5 and SLC45A2—and had darker skin, Science notes.

But hunter-gatherers hunkered down further north in Sweden had both those light-skin genes and also a third gene that leads to blue eyes (and possibly fair skin and blond hair).

When the third demographic, the Near East farmers, arrived, they also carried the SLC24A5 and SLC45A2 genes, so paler skin started emerging throughout the continent as the populations interbred.

Although researchers don’t offer a definitive answer as to why natural selection picked those genes to thrive in the north, one paleoanthropologist speculated at the meeting that the lack of sun in the northern parts of Europe required people to adapt by developing lighter skin to better absorb more vitamin D, as well as the LCT gene that allowed them to digest the sugars their ancestors couldn’t in milk, also filled with vitamin D.

(This one infant could tell us where the first Americans came from.)

This article originally appeared on Newser: Europeans’ White Skin Came Later Than Thought

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Powerful 3D-printed rifle fires NATO rounds

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A 3D printing enthusiast recently created a lower receiver for a high caliber Colt CM901 rifle. (printedfirearm.com)

A group of gunsmiths just 3D printed a bigger, better caliber rifle.

PrintedFirearm.com , a website devoted to 3D printing of guns, announced that one of its members successfully developed a lower receiver for a Colt CM901 rifle. The receiver for the CM901—which is considered to be a much stronger brother of the popular AR-15 assault rifle—was crafted on a XYZ Da Vinci printer, which normally costs around $500 – considered cheap in the 3D printer world. While they were not the first to 3D print a lower receiver, it seems as if Printed Firearm has taken an evolutionary step.

“This is the FIRST EVER 3d Printed AR-10 (CM901/LE901) lower receiver by JT,” reads a blog post on PrintedFirearm.com. “OH YES WE DID!!!!!!! Yes people its pure awesome sauce and it has been tested, fired with little to no issues.”

The CM901 has a similar design to the AR-15 but can fire a heavier and more powerful 7.62 millimeter round, which results in higher range and stopping power. The standard NATO rifle cartridge has a 7.62 mm diameter and a 51 mm case length.

“Is it as strong as metal, no, is it as strong as wood, probably not, is it strong enough to work, yes and it has proven just that.”- PrintedFirearm.com blogger who asked that his name be withheld

The rifle is also a modular weapons system, which allows for multiple modifications, so it is also capable of firing lighter 5.56-millimeter rounds as well.

Printed Firearm posted a five-second GIF of the lower receiver in action at a firing range. Like most 3D printed objects, the part is made from a plastic-like filament so it is not clear how many shots could be fired before it breaks or becomes damaged.

“This receiver is durable enough to work,” The Author of Printed Firearm’s blog, who asked that his name be withheld, told FoxNews.com.  “The reality is the lower receiver in an AR style weapon does not need to be that strong.

“Is it as strong as metal, no, is it as strong as wood, probably not, is it strong enough to work, yes and it has proven just that.”

The blogger adds that the creator of the part claims to have fired over 100 rounds of ammunition without any issues of visible wear and tear.

Blueprints for parts like a lower receiver for the AR-15, have been available on the web to download for several years but this is the first instance where it has been drafted with an affordable printer and has raised the question among some in the community that an affordable rifle — from barrel to stock — will eventually be as simple as hitting the print button.

Others say it will be a long while before that is a reality.

“It’s good for the narrative for the improvements in 3D printing,” Cody Wilson of Defense Distributed, another group that made what was considered the first working 3D printed handgun back in 2013, told FoxNews.Com “But it’s going to be a long time before a rifle can be made on an affordable 3D printer.”

Makeshift gunsmiths have focused mostly on printing lower receivers because it is the only part of the rifle that has federal regulations. Every other part, such as the barrel or the handgrip can be purchased without any sort of permit.

Under current law, there are no federal restrictions on making a gun for personal use – so long as it is under the parameters of both the Gun Control Act and the National Firearms Act.

Officials for the Bureau of Alcohol,Tobacco,Firearms and Explosives told FoxNews.com that they are monitoring developments in 3D printing technology.

“[The] ATF routinely collaborates with the firearms industry and law enforcement to monitor new technologies and current manufacturing trends that could potentially impact the safety of the public,” Dannette Seward, a spokeswoman for the ATF said in a written statement.

Printed Firearm says that the reaction of this latest lower receiver and the low cost will increase the number of hobbyists but would do little in terms of advancing technology.

“At $500 it is something a hobbyist like myself can potentially own,” The blogger said. “The reality is most of us involved in this area of technology are doing it simply to understand what is possible.

“If one wanted to create a stronger, more reliable, item 3D printing would not likely be the best tool to use.”

Perry Chiaramonte is a reporter for FoxNews.com. Follow him on Twitter at@perrych

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New study reveals why you shouldn’t drink coffee from a white mug

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 (iStock)

Think your coffee tastes extra bitter today? You may want to switch mugs.

The color of your cup may be affecting the taste of your morning brew, says a new study released in the online journal Flavour.

The idea for the study was inspired by a barista who overheard customers claiming they thought coffee drunk from a white mug tasted more bitter than drinking from a clear glass container. Researchers conducted a series of experiments where participants drank coffee from white, clear and blue mugs and were then asked to analyze taste.

The study found that coffee drunk from a white cup tastes “significantly more intense”—aka less sweet and more bitter—than drinking from a clear or blue mug.

The reason?

Humans tend to associate color with flavor and white is associated with bitterness. The brown color of the coffee “contrasts” significantly with a white drinking apparatus. Conversely, drinking from a clear cup enhances a drink’s “perceived sweetness.” Blue mugs apparently amplify both sweetness and bitterness, so the brew just tastes stronger overall.

The researchers claim their findings on mug color should “be considered by those serving coffee as it can influence the consumer’s multi-sensory coffee drinking experience.”

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Scientists implant tiny robots inside live mice

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File photo. (Reuters)

Can robots travel inside living animals? It sounds like science fiction, but scientists have just made it a reality by implanting tiny nano-robots inside living mice. Researchers from the Department of Nanoengineering at the University of California, San Diego, published their report on the first successful tests of implanting micro robots designed to disperse drugs within a body, reports SmithsonianMag.com.

As the research report states, these kinds of robots have been tested “in vitro,” or outside the body, in the past, while this is the first time that this technology has been studied “in vivo,” or inside the body. The zinc-based robots — only the width of a strand of human hair — were ingested orally by the mice. The zinc reacted with the animal’s stomach acid, producing hydrogen bubbles that propelled the robots into the stomach lining. As soon as the robots attached to the stomach, they dissolved, delivering the medicine into the stomach tissue, i09 reports.

For the researchers, this work could pave the way for implanting similar robots in humans. This could be an effective way of delivering drugs to the stomach in order to treat something like a peptic ulcer, the BBC reports.

“While additional ‘in vivo’ characterizations are warranted to further evaluate the performance and functionalities of various man-made micromotors in living organisms, this study represents the very first steps toward such a goal,” reads the research report. According to the researchers, this work moves toward “expanding the horizon of man-made nanomachines in medicine.”

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How to drink a perfect whisky

I am doing it wrong…  I like a whisky stone in mine.  It chills it without diluting it.  First though, the spelling is important:

The difference between whiskey and whisky is simple but important: whisky usually denotes Scotch whisky and Scotch-inspired liquors, and whiskey denotes the Irish and American liquors.

The word itself (both spellings) is of Celtic origin, and modern whisky/whiskey distillation practices originated in Ireland and Scotland. Using whiskey to refer to Scotch whisky can get you in trouble in Scotland.

Now for the story written by Ali Rosen…

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There are very few hard and fast rules when drinking whisky. (iStock)

There are few drinks in life enjoyed as simply and purely as a glass of Scotch – and equally as few that have as much history and as many opinions contained in a single glass.

But is there a proper way to drink your whisky?

The perfect pour: “preferably more than a gnat could consume and less than an elephant would. “

With so many claims of right and wrong surrounding the beloved drink, we went straight to the Scottish experts to make sure we’re drinking whisky as perfectly as possible.

And the one thing we learned straightaway is that throwing out your rule book is a perfect place to begin.

No perfect pour

For starters, there isn’t even a standard pour.  Most experts recommend between one and two ounces should be served to you or a guest, but there are no hard and fast rules.

“A dram of whisky – the measurement we use to describe a pour – is an amount of whisky that the person pouring is happy to share from their bottle, and the person receiving is grateful to be given,” Nicholas Pollacchi, the founder of Whisky Dog and the whisky category director for Anchor Distilling Company says.

David Cox, the rare malts director for The Edrington Group – which includes The Macallan and Highland Park – concurs. His estimation is that you should pour, “preferably more than a gnat could consume and less than an elephant would,” but he does note that whatever you pour there should be head space in the glass for the whisky to breathe.

Don’t compromise on the glassware

There’s a common misconception that whisky should go in a rocks glass – or worse, in a shot glass. But the most commonly agreed upon vessel is the nosing glass. The tulip shaped glass help to concentrate the aromas in one point.

“Alcohol rises from the glass at different times,” Pollacchi explains. “They have weight to them, so the lighter, floral and sweeter notes will rise first, followed by heavier, darker and richer aromas. By using a glass that pulls these aromas to one point, you can fully appreciate the complexities within each dram.”

But Carl Reavey, from Bruichladdich Scotch whisky, maintains that for social drinking, you can use a wine glass or brandy balloon because “it is essential to have the ability to swirl the spirit in the glass and for the glass to have a bowl capable of retaining the aroma.”

Neat and water are okay, but no rocks

Once you have your whisky in hand – with the right glassware – there is agreement that whisky should probably be enjoyed without the rocks, since it dulls flavors.

Most recommend starting with it neat (without any additions) and then slowly adding water. The Balvenie distillery’s David Laird explains that this “is essential for detecting aromas as well as flavor on the pallet. This will allow you to open up the whisky and enjoy all of the flavor and aromas.”

Cox concurs, noting that “spring water at room temperature is the best accompaniment to allow the character to shine through, reducing some of the stronger alcoholic volatiles on the nose.”

But unlike glassware, this is an area that all the whisky-lovers admit needs to be a personal choice. Pollacchi insists that despite expert preferences it’s important to not be precious about how to drink whisky. It should instead be about, “allowing every person to find a path that allows them to find the most enjoyment from every whisky they try.”

But whether you’re defying the experts by adding ice or slowly adding water, it’s important that when it comes to drinking you take your time and whatever choice of Scotch you’ve made.

Sipping in steps

If you want to truly appreciate a great whisky – the process can involve many steps.

For example, when Bruichladdich master distiller Jim McEwan tastes, he starts by looking at the color, swirling and then looking at the legs on the glass. He looks at the color again, swirls, and then noses again followed by a first taste, usually by dipping a finger in. Then after another taste he adds some water carefully down the side of the glass, swirls and tastes again.

“You are looking for flavor and aromas, not alcohol. Introducing your nose to the whisky gradually will allow you to judge the perfect distance from the glass you prefer, so that you savor the most aromas without the alcohol desensitizing your senses,” Laird explains.

No matter the routine, all the experts stress that the key is in taking your time and enjoying when you have a great whisky in your hand without a feeling that there is a specific routine that must be followed.

“I have sometimes sat with a glass and just enjoyed intermittently nosing it for 5 to 10 minutes, savoring the complexities before rewarding myself with an eventual sip,” Pollacchi says.

Cox concurs noting that tasting your whisky is inexact, and should take long “enough for the aromas and flavors to envelope you.”

And if you’re sharing whisky with friends, don’t forget to toast.

The Scottish phrase Slàinte Mhath – Gaelic for ‘good health’ – is traditional, but just ensuring that the moment is savored is essential.

If you’re drinking a great whisky whose tradition has been honed over decades and aged to perfection the key element is to take your time and enjoy. And, as Cox points out, to stay upright.

Slàinte mhath!

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Excavation at Oregon site unearths ancient stone tool

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This undated photo provided by the University of Oregon Museum of Natural and Cultural History shows a scraper chipped out of agate found at an ancient rock shelter in the high desert of eastern Oregon. (AP)

Archaeologists unearthed a stone tool at an ancient rock shelter in Oregon that could be older than any known site of human occupation in western North America.

The hand-held scraper was chipped from a piece of orange agate that is not normally found in eastern Oregon. The tool was found about eight niches below a layer of volcanic ash from an eruption of Mount St. Helen’s dated from about 15,000 years ago. The depth was about 12 feet below the surface.

The U.S. Bureau of Land Management announced the find Thursday. An archaeologist from the agency, Scott Thomas, said that if the age of the site holds up to scrutiny, it would be the oldest west of the Rockies, predating the Clovis culture that is believed to be the first people to migrate from Asia to North America about 13,000 years ago.

University of Oregon archaeologist Patrick O’Grady supervises the dig at the Rimrock Draw Rockshelter. He called the find “tantalizing,” but hopes to find out if the volcanic ash covers the entire area.

Donald K. Grayson, professor of archaeology at the University of Washington, said the scientific community would be skeptical.

“No one is going to believe this until it is shown there was no break in that ash layer, that the artifact could not have worked its way down from higher up, and until it is published in a convincing way,” he said. “Until then, extreme skepticism is all they are going to get.”

Two pre-Clovis sites are generally accepted by scientists, Grayson said. One is Paisley Cave, 60 miles southwest of the Rimrock site and another is in Mount Verde, Chile. Both are dated about 1,000 years before the oldest Clovis sites.

The find has yet to be submitted to a scientific journal for publication, but it has been reported in newsletters and at conferences, Thomas said.

Thomas found the site several years ago, while taking a break from carrying supplies to a session of the University of Oregon Archaeological Field School nearby that O’Grady was overseeing.

Thomas said he noticed an outcropping of an ancient lava flow, with some very tall sage brush growing in front of it, indicating very deep sediment deposits. The soil was black in front of the rock, indicating someone regularly built cooking fires there for a long time. An ancient streambed ran by, which would have given people more reason to stay there. And on the surface, he found a stone point of the stemmed type, found at sites both older and younger than Clovis. Similar points have been found at Paisley Cave.

The Associated Press contributed to this report

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Herbie the Love Bug sold for $32,100

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 (racingbug53)

The world’s most famous water “bug” has surfaced on Ebay.

One of the Volkswagen Beetles built for the “Herbie the Love Bug” movie franchise was sold Thursday on the auction site for $32,100.

It was featured in the 1980 film “Herbie Goes Bananas” and was one of two specially built for a scene where it sails through the Panama Canal.

According to the seller, the 1963 car had its engine, transmission and front suspension removed, and fiberglass wheels added, to help it float, and was sold as a parts car without title when production of the film was complete. From there, it ended up in California wrecking yard where it sat for several years.

A previous owner purchased it and replaced the rotted floorpan, which brought with it a new title. The current seller then added a working drive train with a 1.6-liter engine and 4-speed transmission.

The car runs and is road legal, features the faux-rusty paint job seen on screen, and was sold with a collection of extra parts that were used during filming.

And if its authentication documents aren’t good enough for you, it has a remote control that can move its headlights back and forth and use its windshield washers to squirt people.

It is a water bug, after all.

———-

 

 

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Largest trove of gold coins in Israel unearthed from ancient harbor

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 (Israel Antiquities Authority)

A group of divers in Israel has stumbled upon the largest hoard of gold coins ever discovered in the country. The divers reported the find to the Israel Antiquities Authority, and nearly 2,000 coins dating back to the Fatimid period, or the eleventh century, were salvaged by the authority’s Marine Archaeology Unit. The find was unearthed from the seabed of the ancient harbor in Caesarea National Park, according to a press release from the Israel Antiquities Authority.

“The discovery of such a large hoard of coins that had such tremendous economic power in antiquity raises several possibilities regarding its presence on the seabed,” said Kobi Sharvit, director of the Marine Archaeology Unit of the Israel Antiquities Authority, in the release. “There is probably a shipwreck there of an official treasury boat which was on its way to the central government in Egypt with taxes that had been collected.”

Sharvit suggested that the treasure trove of coins might have been intended to pay the members of the Fatimid military garrison stationed at Caesarea, Israel. There are also other theories as the origins of the coins. Sharvit said that the coins could have belonged to a sunken merchant ship.

“The coins are in excellent state of preservation, and despite the fact they were at the bottom of the sea for about a thousand years, they did not require any cleaning or conservation intervention,” said Robert Cole, an expert numismaticist – someone who studies currency – with the antiquities authority.

The five divers have been called “model citizens” by the antiquities organization. Had the divers removed the objects from their location or tried to sell them, they could have faced a sentence of up to five years in prison.

The oldest of the coins is a quarter dinar that was minted in Palermo, Sicily during the second half of the ninth century. The majority of the coins can be traced back to the Faimid caliphs, Al-Ḥākim and his son Al-Ẓāhir who were alive in during the eleventh century. These coins were minted in Egypt and North Africa.

“There is no doubt that the discovery of the impressive treasure highlights the uniqueness of Caesarea as an ancient port city with rich history and cultural heritage,” stated the Caesarea Development Company and Nature and Parks Authority in the release. “After 2,000 years it is still capable of captivating its many visitors … when other parts of its mysterious past are revealed in the ground and in the sea.”

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2 planets may lurk in solar system beyond Pluto, study says

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March 26, 2014: A newly discovered planet-like object, dubbed “Sedna” is seen in this artist’s concept released by NASA. (AP)

There is evidence of at least two planets larger than Earth lurking in our solar system beyond Pluto, a new analysis of “extreme trans-Neptunian objects” reveals.

After studying 13 of these “extreme trans-Neptunian objects,” or ETNOs, the obits of these objects are different from a theory that predicts the orbits.

“The exact number is uncertain, given that the data that we have is limited, but our calculations suggest that there are at least two planets, and probably more, within the confines of our solar system,” Carlos de la Fuente Marcos, scientist at the UCM and co-author of the study, said in a statement Friday.

Theory says these objects should have an average distance to the sun of 150 astronomical units. These orbits should also have an inclination of 0 degrees, Space.com says.

However, the orbits of the ETNOs have semi-major axes ranging from 150-525 astronomical units and inclinations of about 20 degrees.

These potential worlds would be bigger than Earth and would lie nearly 200 astronomical units from the sun. Earth is one astronomical unit from the sun.

The new results may give way to evidence of the existence of Planet X, which is a rumored object as far away as 250 astronomical units from the sun and 10 times larger than Earth.

With the current instruments available to scientists, it is nearly impossible to spot these objects.

Click for more from Space.com.

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