Tag Archives: Denis Malyshev of the Scripps Institute

This Mysterious Underground Building Still Baffles Everyone

This Mysterious Underground Building Still Baffles Everyone
Word spread, and a local schoolteacher soon volunteered his young son, Joshua, to be lowered into the hole with a candle. If you think dipping your child into a mysterious cavern in the Earth seems a bit, well, unsafe, we do, too. Luckily, Joshua was fine, and what he saw underground was a breathtaking mystery.

When Joshua was pulled out, he described rooms filled with hundreds of thousands of carefully arranged shells.

Needless to say, the adults were a bit skeptical, but when the hole was widened and they saw if for themselves, they were stunned. There was a passage, a rotunda, and an altar chamber, and the whole thing was covered in a mosaic of shells.

Joshua’s father, the schoolteacher, immediately thought of the financial benefit that this place might have. He quickly bought up the land and began renovating the grotto, making it suitable for visitors. Two years later, in 1837, the Margate Shell Grotto opened to the public for the first time. And he was right; it did catch on with the public, and it’s still open and enjoying visitors today. Today, it’s also got a museum, gift shop, and cafe.

But there’s still a major question hanging in the air: who built this, and why?

With all these shells so carefully arranged, it’s clear that someone spent a lot of time — and money — on this creation. The shells are arranged in sun and star shapes, and vaulted ceilings and altar-like spaces lead some to believe it once had religious significance. Yet no one knows for sure, and no one is even sure how old the structure is.

Theories about its origin place it as being built as long as 3,000 years ago.

Other theories also run the gamut between ordinary and totally out there. Some think it was created as an aristocrat’s folly sometime in the 1700s. Others think it might have been used as an astrological calendar, or that it’s connected with the Freemasons or the Knights Templar. Still, others maintain it is connected to a mysterious Mexican culture that lived some 12,000 years ago.

Shell grottoes were actually quite popular in Europe in the 1700s among the wealthy.

There’s only one catch: the Grotto’s location was on farmland, and that land has never been part of a large estate, where follies would have been built. Even in 1835, there was no record of its construction, which would have been a major undertaking. People have been so stumped by this that in the 1930s, people held seances in the hopes of contacting the spirits of whoever built it.

Visitors from the 1930s left their mark on some scallop shells in the grotto.

The shells in the grotto, which include scallops, whelks, mussels, cockles, limpets, and oysters, can all be found locally. Only the flat winkle shells had to be brought in from elsewhere.

The arrangement of the shells must have taken countless hours of painstaking work.

In all, there are over 2,000 square feet of shell mosaic in the grotto.

Many of the shells in the grotto have faded over time and lost their luster through water damage. This recreation shows what they might have looked like at the time the grotto was built. It would have been full of dazzling color.

(via Kuriositas, Wikipedia)

To determine the age of the shells, they could be carbon dated. However, on the Shell Grotto’s FAQ page, it’s stated that this process is very expensive, and other conservation issues are currently prioritized. Perhaps one day, we’ll at least know when this was built. For now, our imaginations can run wild with all the possibilities of the Shell Grotto’s mysterious past. Was it a smuggler’s hideout? A secret temple? An underground party room? The life’s work of a madman? Whatever it was, someone obviously cared about it enough to decorate it like this.

Read more: http://www.disclose.tv/news/this_mysterious_underground_building_still_baffles_everyone/118943#ixzz3ehCnw7IJ

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New life: Scientists create first semi-synthetic organism with ‘alien’ DNA

SCIENCE EDITOR
Wednesday 07 May 2014

The researchers believe the breakthrough is the first step towards creating new microbial life-forms with novel industrial or medical properties resulting from a potentially massive expansion of genetic information.

The semi-synthetic microbe, a genetically modified E. coli bacterium, has been endowed with an extra artificial piece of DNA with an expanded genetic alphabet – instead of the usual four “letters” of the alphabet its DNA molecule has six.

The natural genetic code of all living things is based on a sequence of four bases – G, C, T, A – which form two sets of bonded pairs, G to C and T to A, that link the two strands of the DNA double helix.

The DNA of the new semi-synthetic microbe, however, has a pair of extra base pairs, denoted by X and Y, which pair up together like the other base pairs and are fully integrated into the rest of the DNA’s genetic code.

The scientists said that the semi-synthetic E. coli bacterium replicates normally and is able to pass on the new genetic information to subsequent generations. However, it was not able to use the new encoded information to produce any novel proteins – the synthetic DNA was added as an extra circular strand that did not take part in the bacterium’s normal metabolic functions.

The study, published in the journal Nature, is the first time that scientists have managed to produce a genetically modified microbe that is able to function and replicate with a different genetic code to the one that is thought to have existed ever since life first started to evolve on Earth more than 3.5 billion years ago.

“Life on earth in all its diversity is encoded by only two pairs of DNA bases, A-T and C-G, and what we’ve made is an organism that stably contains those two plus a third, unnatural pair of bases,” said Professor Floyd Romesberg of the Scripps Research Institute in La Jolla, California.

“This shows that other solutions to storing information are possible and, of course, takes us closer to an expanded-DNA biology that will have many exciting applications, from new medicines to new kinds of nanotechnology,” Professor Romesberg said.

Expanding the genetic code with an extra base pair raises the prospect of building new kinds of proteins from a much wider range of amino acids than the 20 or so that exist in nature. A new code based on six base pairs could in theory deal with more than 200 amino acids, the scientists said.

“In principle, we could encode new proteins made from new, unnatural amino acids, which would give us greater power than ever to tailor protein therapeutics and diagnostics and laboratory reagents to have desired functions,” Professor Romesberg said.

“Other applications, such as nanomaterials, are also possible,” he added.

The researchers emphasised that there is little danger of the new life-forms living outside the confines of the laboratory, as they are not able to replicate with their synthetic DNA strand unless they are continuously fed the X and Y bases – synthetic chemicals called “d5SICS” and “dNaM”, that do not exist in nature.

The bacteria also need a special protein to transport the new bases around the cell of the microbe. The transporter protein comes from algae and if it, or the X and Y bases, are lacking, the microbial cells revert back to the natural genetic code, said Denis Malyshev of the Scripps Institute.

“Our new bases can only get into the cell if we turn on the “base transporter” protein. Without this transporter or when the new bases are not provided, the cell will revert back to A, T, G, C and the d5SICS and the dNaM will disappear from the genome,” Dr Malyshev said.

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